Nobel Prize-Winning Frances Arnold Now Earns 2019 Bower Award for Achievement in Science

first_img Community News 6 recommendedShareShareTweetSharePin it Chemical engineer Frances Arnold Credit: Caltech“We rely on the modern chemical industry to bring us everything from prescription drugs to paper, but making these products often involves toxic chemicals and costly, energy-hungry processes.” While enzymes—biological catalysts made of protein—have long been proposed as a potential green solution for chemical manufacturing, engineering useful enzymes has proved immensely difficult.In the early 1990s, Frances H. Arnold, the Linus Pauling Professor of Chemical Engineering, Bioengineering and Biochemistry, found a solution in a method known as directed evolution that she developed for creating new and useful versions of enzymes. Her research revolutionized enzyme design and in 2018 she won the Nobel Prize in Chemistry.Now, Arnold has been named the winner of the 2019 Bower Award for Achievement in Science. The Bower Award is among the prestigious Franklin Institute Awards, which have honored exceptional innovators in science and technology since 1824. Arnold was honored for “pioneering the development of directed protein evolution,” a monumental step forward in the science of protein engineering that revolutionized the use of biological catalysts for research and industry.Directed evolution takes a page out of nature’s playbook. Biological enzymes evolved over billions of years through random mutations and natural selection. Arnold realized that she could do something similar by selectively “breeding” new proteins for specific traits in much the same way we have guided the evolution of livestock and crops. This allowed her to create enzymes with specific, novel chemical properties.Designing a new biological catalyst through directed evolution starts with mutation of the DNA that encodes an already existing enzyme. Thousands of mutant enzymes are created from the starting enzyme and screened for a desired trait. Those enzymes that perform well are put through the same process of mutation and selection repeatedly, each generation enhancing the enzyme’s performance. This technique is so effective that it can persuade enzymes to perform reactions not found in nature; the Arnold group has created enzymes capable of making silicon-carbon bonds, boron-silicon bonds, and high-energy carbon rings called bicyclotubanes.Arnold, who is also the director of the Donna and Benjamin M. Rosen Bioengineering Center, hopes that as directed-evolution technologies grow and advance, they will increasingly supplant more traditional chemical processes, and that the day will come when much of chemical manufacturing will be performed not by humans, but by bacteria with engineered enzymes. Pasadena’s ‘626 Day’ Aims to Celebrate City, Boost Local Economy Subscribe Home of the Week: Unique Pasadena Home Located on Madeline Drive, Pasadena People Nobel Prize-Winning Frances Arnold Now Earns 2019 Bower Award for Achievement in Science By ELISE CUTTS Published on Tuesday, February 12, 2019 | 5:08 pm Community News First Heatwave Expected Next Week Get our daily Pasadena newspaper in your email box. Free.Get all the latest Pasadena news, more than 10 fresh stories daily, 7 days a week at 7 a.m. Top of the News center_img Make a comment Pasadena Will Allow Vaccinated People to Go Without Masks in Most Settings Starting on Tuesday HerbeautyRub This All Over Your Body And He’s Guaranteed To Swoon Over YouHerbeautyHerbeautyHerbeautyThese Fashion Tips Are Making Tall Girls The Talk Of The TownHerbeautyHerbeautyHerbeautyHe Is Totally In Love With You If He Does These 7 ThingsHerbeautyHerbeautyHerbeauty10 Questions To Start Conversation Way Better Than ‘How U Doing?’HerbeautyHerbeautyHerbeautyHere Is What Scientists Say Will Happen When You Eat AvocadosHerbeautyHerbeautyHerbeautyThe Most Heartwarming Moments Between Father And DaughterHerbeautyHerbeauty More Cool Stuff EVENTS & ENTERTAINMENT | FOOD & DRINK | THE ARTS | REAL ESTATE | HOME & GARDEN | WELLNESS | SOCIAL SCENE | GETAWAYS | PARENTS & KIDS Name (required)  Mail (required) (not be published)  Website  faithfernandez More » ShareTweetShare on Google+Pin on PinterestSend with WhatsApp,Virtual Schools PasadenaHomes Solve Community/Gov/Pub SafetyCitizen Service CenterPASADENA EVENTS & ACTIVITIES CALENDARClick here for Movie Showtimes Business News Your email address will not be published. Required fields are marked *last_img read more

Limerick’s ‘Men’s Health Week’ shines a light on preventable health problems

first_img16/06/2015Limerick Mens Health Week launch.Pictured helping to launch the event were, Dylan Kelly, Kileedy, Co. Limerick, Peter Coker, Abbeyfeale Co. Limerick and Jason Brouder, Monagea Co. Limerick. Picture: Alan Place/FusionShooters. 16/06/2015Limerick Mens Health Week launch.Pictured helping to launch the event were, Jason Brouder, Monagea, Co. Limerick, Denis Collins, Abbeyfeale, Finbar Ahern, Castleconnell, Gearoid Balfry, Patrickswell, Peter Croker, Abbeyfeale and Luke Kennedy, Limerick Sports Partnership. Picture: Alan Place/FusionShooters. TAGSinternational men’s health weeklimerickmen’s health week The annual initiative also aims to support men and boys to engage in healthier lifestyle choices and activities, as well as encourage the early detection and treatment of health difficulties in males.Limerick Sports Partnership hosted a calendar of events across Limerick City and County during the week. “Adopting a healthy lifestyle is not something that can easily happen overnight but small changes can make a big difference. Our focus over the past week was to inform men about the lifestyle changes that will make them live longer and healthier lives,” added Ms. Fitzgerald. Advertisement The LSP were delighted to have Lorcan Brennan present during the week who delivered the Men’s Development Network ‘Engage Training’ and also launched the LSP upcoming Men on the Move Health Checks Initiative to practitioners working with men across Limerick City and County. Vanishing Ireland podcast documenting interviews with people over 70’s, looking for volunteers to share their stories Facebook Predictions on the future of learning discussed at Limerick Lifelong Learning Festival “Figures show men on the island of Ireland experience a disproportionate burden of ill-health with one man in five dying before the age of 65. Many of those deaths are preventable, so this year’s Men’s Health Week contained a strong focus on men pursing a healthy lifestyle,” commented Mairead Fitzgerald, Sports Development Officer at Limerick Sports Partnership. Print NewsLimerick’s ‘Men’s Health Week’ shines a light on preventable health problemsBy Staff Reporter – June 22, 2015 885 The week was supported by the Men’s Health Forum in Ireland (MHFI), HSE, Bikeweek 2015, Men’s Development Network, UL Sport and LIT. RELATED ARTICLESMORE FROM AUTHOR Among the events was an open swim session at UL Sports Arena, Go For Life Games at LIT Sports Hall, Walking Soccer in Abbeyfeale Astro Turf Pitch, a men’s health awareness event at Woodlands House Hotel in Adare, a Great Southern Trail Cycle and a men’s health physical activity information stand at the Daffodil Centre in the Mid Western Regional Hospital. Limerick’s National Camogie League double header to be streamed live WATCH: “Everyone is fighting so hard to get on” – Pat Ryan on competitive camogie squads Hundreds of Limerick men of all ages took part in a series of events marking International Men’s Health Week, which came to a close at the weekend. Email Twitter Previous articleRail tours from Shannon to boost tourismNext articlePictures – Down Syndrome Ireland Night at the Dogs Staff Reporter Celebrated in most European countries, as well as in the USA, Australia, New Zealand and a number of other places worldwide, Men’s Health Week aims to heighten awareness of preventable health problems for males of all ages. Linkedin 16/06/2015Limerick Mens Health Week launch. Picture: Alan Place/FusionShooters. 16/06/2015Limerick Mens Health Week launch.Pictured helping to launch the event were, Finbar Ahern, Castleconnell, Co. Limerick, Aine Cunningham, Kileedy Co. Limerick and Denis Collins, Abbeyfeale, Co. Limerick. Picture: Alan Place/FusionShooters. Limerick Artist ‘Willzee’ releases new Music Video – “A Dream of Peace” WhatsApp Limerick Ladies National Football League opener to be streamed livelast_img read more

NBA free agency winners and losers: Nets rise, Knicks fall and Lakers wait on Kawhi Leonard

first_imgNBA FREE AGENCY 2019: Follow SN’s live rumors trackerKawhi Leonard is still on the board, of course, though his decision is reportedly down to the Clippers, Lakers and Raptors. The rest of the free agents are largely role players searching for an opportunity rather than a huge payday.So with that in mind, let’s roll through the early winners and losers from free agency. (The winners and losers are subject to change. We’re working with what we’ve got so far.)NBA free agency winnersBrooklyn NetsWhat an incredible turnaround. In three years, Nets general manager Sean Marks somehow took a franchise with no significant assets and rebuilt it from the ashes — and he didn’t go full “Trust the Process” to pull it off. Brooklyn is in position to be a contender over the next few seasons.There is a certain amount of risk in signing KD and Kyrie. Durant may never be the same player again after rupturing his Achilles. Irving has unceremoniously left his last two teams. How will this sudden shift impact the mentality of their new teammates?But this is a swing for the fences any front office would take. The 2018-19 Nets capped out as a fun playoff team. This new group has championship potential. DeAndre JordanFour years and $40 million? With Jarrett Allen already on the Nets? In this economy?It helps to be friends with Durant and Irving.Indiana PacersThe Pacers lost Bojan Bogdanovic and Thaddeus Young in free agency, two key contributors who helped keep Indiana afloat when Victor Oladipo went down with a quad injury.However, the Pacers recovered nicely by snagging Malcolm Brogdon from the Bucks and adding Jeremy Lamb on a team-friendly contract (three years, $31 million). Brogdon and Lamb offer some much-needed offense next to Oladipo. And with Brogdon and Lamb at 26 and 27 years old, respectively, there is potential for improvement in the right environment.They didn’t acquire a superstar, but the Pacers may have improved after a 48-win season.Utah JazzDon’t look now, but the Jazz could be the team to beat in the Western Conference next season.Trading for Grizzlies guard Mike Conley was huge considering how much weight had been put on Donovan Mitchell’s shoulders the past two years, but Utah didn’t stop there. The Jazz signed Bogdanovic, Ed Davis, Jeff Green and Emmanuel Mudiay, providing some depth at multiple positions.Ahead of opening night, the Jazz could be looking at a starting five of Conley, Mitchell, Bogdanovic, Joe Ingles and Rudy Gobert. Good luck trying to score against that.And so it begins….— Donovan Mitchell (@spidadmitchell) June 30, 2019New Orleans PelicansPresident of basketball operations David Griffin accepted the challenge of flipping the page on the Anthony Davis era and leading the Pelicans into the future. He’s pretty much nailed it every step of the way.New Orleans got young prospects (Lonzo Ball, Josh Hart, Brandon Ingram), a pile of picks and a partridge in a pear tree from the Lakers in the Davis trade. The Pels selected Zion Williamson, Jaxson Hayes and Nickeil Alexander-Walker in the draft. Then they got Derrick Favors and JJ Redick in free agency.Favors can play center if Pelicans coach Alvin Gentry prefers to slide Hayes and Williamson away from traditional NBA bigs in their rookie seasons. Redick is one of the NBA’s elite 3-point threats and will create spacing as penetrators like Jrue Holiday and Ball attempt to create offense.This might not be a playoff team in the West immediately, but the pieces are coming together.Klay ThompsonMax money from the Warriors (five years, $190 million) and an outstanding Instagram announcement. Klay wins. View this post on Instagram The NBA free agency period began only a few days ago, but a large portion of the 2019 free agent class has already found landing spots.Kevin Durant and Kyrie Irving are heading to Brooklyn. Jimmy Butler is taking his talents to South Beach. Kemba Walker will replace Irving in Boston. Tobias Harris and Al Horford both chose Philadelphia, helping to form one of the biggest teams in league history. The BoardroomFollow The Boardroom Instagram account for the Durant decision!Source: Kevin Durant will announce his free agent decision tonight on his company owned sports business network:— Adrian Wojnarowski (@wojespn) June 30, 2019WOJ AIN’T GOT TIME FOR THAT.Kevin Durant is planning to sign with the Brooklyn Nets, league sources tell ESPN.— Adrian Wojnarowski (@wojespn) June 30, 2019To be determined . . .The Kawhi Leonard suitorsThe Clippers, Laker and Raptors are all-in on Leonard. Much like the Highlander, there can only be one! Mood (there was never a doubt) #warrior4lifeA post shared by Klay Thompson (@klaythompson) on Jul 1, 2019 at 12:27pm PDTNBA free agency losersNew York KnicksAn annual reminder New York missed its targets in free agency. Sorry, Knicks fans.It stings a little bit more this time knowing Durant and Irving are choosing the other team in New York City. It appeared the Knicks were in the lead for both free agents the entire season, but clearly creating a culture and identity mattered more than “The Garden” and a championship history most current players weren’t alive to see. Go figure!The Knicks switched gears and signed Julius Randle, a defensible contract on its own (three years, $63 million). After that, though? Bobby Portis, Taj Gibson, Reggie Bullock, Elfrid Payton and Wayne Ellington. Instead of utilizing their cap space to take on bad contracts and picks as sweeteners, the Knicks offered deals for the sake of… offering deals.New York is stuck in a cycle of incompetence. As long as James Dolan is at the top of the organizational chart, it doesn’t feel like that will change.Orlando MagicThe Magic finished as the East’s No. 7 seed under coach Steve Clifford in 2018-19, reaching the playoffs for the first time since 2011-12. It was a surprising success.That doesn’t mean Orlando should have essentially run this team back. The Magic are hoarding frontcourt players in a bunker big enough for all of their arms. They’ve got Nikola Vucevic, Aaron Gordon, Jonathan Isaac, Mo Bamba, Al-Farouq Aminu and first-round pick Chuma Okeke. Plus, Khem Birch is a restricted free agent.Will the Magic stack all of these guys up in front of the rim? This is confusing.Charlotte HornetsThe Hornets lost their top two scorers in Walker and Lamb. They gave Terry Rozier a three-year, $58 million contract.So rather than giving Walker a supermax or traditional max — or even trading him at last year’s deadline — Charlotte felt it was best to let him walk and sign an unproven gunner as his replacement.To any Hornets fans wondering how to handle this, just go outside. Take a walk. Read a book. Enjoy a taco. It’s all bad news at the Spectrum Center.Minnesota TimberwolvesMarc Stein of The New York Times reported Timberwolves star Karl-Anthony Towns had met with D’Angelo Russell ahead of free agency with Minnesota figuring out what trades would be necessary in order to sign the 23-year-old point guard. A one-two punch of Towns and Russell would have given the Timberwolves a chance to both make a playoff push and build a strong foundation.Then the Warriors swooped in and stole Russell away from the Timberwolves. Just like that, Minnesota is back to Towns and not much else.Hey, maybe this is the year Andrew Wiggins finally… nope, nevermind.last_img read more