Because once you’ve compared a government-wide ban prohibiting members of the next administration’s transition team from so much as entering federal buildings to a television talk show host making riffs, you have both sides yourself, orbital cannon version, into the Earth’s asthenosphere.We are likely to get quite a bit of this, in coming weeks. Yes, fascist legislators in several states are contemplating how to strip their citizens of their votes and instead allocate their own electors to Dear Leader—but Randy Rainbow released a new song that made people who have Trump flags permanently mounted to their cargoless pickup trucks sad. It is upsetting that the United States president, a deluded malignant narcissist whose incompetence has killed a quarter million, is obsessively broadcasting conspiracy theories in an attempt to undermine a democratic election that upset him, but a political cartoonist has colored Trump in with far too orange a hue—so who is the real monster here, when all is said and done?To political journalists as a whole, both sides is an addiction more powerful than crack. Combine it with a Fox News paycheck and several floors of the Fox building solely dedicated to finding new things non-conservatives have done that their audience should be outraged by, though, and it begins to look something like this.- Advertisement – It’s been a while, hasn’t it? Good times, good times.Kurtz defended his tweet to the many, many mockers, sniffily telling them to read his Fox News article rather than, um, the “both sides” comparison he himself chose to highlight, but ’twas all for naught.- Advertisement – – Advertisement –
Versailles, IN—The Ripley County Council will hold a special meeting on Monday, June 24th at 7 pm in the Annex to discuss the 2020 budget.
COLUMBIA, Mo. — From day one, he was Nathaniel Hackett’s project.Gone was Greg Paulus, the local kid turned one-year wonder who tried and failed to bring football success to Central New York. Gone was Mike Williams, the program’s best receiver in quite some time who tried and failed to finish the season in a Syracuse uniform.Left behind was Ryan Nassib, the quiet and unassuming Pennsylvania product who waited — and waited — for the Paulus experiment to run its course. And fresh on the scene in 2010 was Hackett, the son of a coach whose meticulous preparation and offensive genius prompted Tyrone Wheatley to call him a “mad scientist.”Hackett the teacher and Nassib the pupil would be two of the principal faces in Doug Marrone’s mission to rebuild his alma mater. The innovation and cunningness of the former combined with the toughness and arm strength of the latter would reconstruct an offense that suffered through a decade of stagnation and resurrect a once-proud program.At least that was the plan.AdvertisementThis is placeholder text“This was my first job,” Hackett said late Saturday night outside Memorial Stadium. “When I got him the first time and he looked at me like I was crazy as this young guy coming in with this, ‘What the heck are you doing?’ stuff to now, where we are, where our relationships has been and him buying into me. It’s been a dream for a first job.”Hackett beamed while speaking of his relationship with Nassib only minutes after the pair had conjured up another fourth-quarter comeback — two of them in fact — with the final touchdown in the closing seconds sealing an improbable victory over Missouri.His quarterback had shined from start to finish on an unseasonably warm day in what is now Southeastern Conference territory. Against a blitz-happy defense and a rowdy crowd of more than 63,000, Nassib stood tall and produced a game for the ages. His passing was masterful, his command of the offense impeccable, and by game’s end he’d passed Marvin Graves to become the all-time leading passer at Syracuse.And perhaps, quite possibly he had cemented himself as the best quarterback his school had ever seen.“I would say, you know, he’s the face of the program,” wide receiver Alec Lemon said. “He does all the right things, everyone is behind him, he’s a leader and everything he does is right.”On Saturday that meant orchestrating a seven-play, 81-yard scoring drive with 1:43 remaining in the game. Nassib threw for all 81 yards on the possession, connecting with Lemon on every pass, and remained unfazed while the Tigers threw all-out blitz after all-out blitz in his direction.But in the bigger picture, doing everything right has meant performing with a consistency that his other teammates have often failed to match. As Lemon and fellow receivers Marcus Sales and Jarrod West have faded in and out of relevancy, as the faces along his offensive line have changed over the last two seasons and as his team’s defense plays Jekyll and Hyde from time to time, Nassib just continues to compile numbers bordering on unimaginable for a Syracuse quarterback.Six games of more than 300 yards passing this season. Four games with three or more touchdowns. An upset of a top-10 team in the BCS standings.And don’t forget the two heroic comebacks, first against South Florida and most recently against Missouri.The student has impressed his teacher.“It will never be noticed enough,” Hackett said. “Nobody will ever understand how good he really is and how hard he works and how passionate he is about this game.”And because of his latest bit of magic — Nassib finished with 385 yards and two touchdowns against Missouri — he will have a chance to add a second bowl victory to his resume. Nassib broke loose with a brilliant performance in the Pinstripe Bowl in 2010, setting the stage for a follow-up season that many thought would end with a similar result — a bowl victory.But 2011 brought severe disappointment in the form of five straight losses and a 5-7 overall record. It ate at Nassib, his receivers, his coaches. They yearned to amend for their failures — both personal and medical — by washing away the awful taste that lingered in their mouths for the better part of eight months.At the head of the movement was Nassib, whose laid-back demeanor with the media is traded for fiery passion inside the Syracuse locker room. He is doing whatever it took for this team and this program to win, even if it means running a zone-read system where his mediocre foot-speed is less than ideal.“What can you say?” Marrone asked rhetorically in his postgame press conference. “I don’t really know. Ryan is getting better and better each week.”And after perhaps the best and most meaningful performance of his career — the Orange earned its first win over an SEC opponent since 2001 — Hackett’s project took the podium with a horse voice and his trademark smug smile.This was his moment after a game he’d dominated. So the face of the program grinned.Said Nassib: “It was fun.” Comments Facebook Twitter Google+ Published on November 18, 2012 at 8:31 pm
WASHINGTON — The U.S. Supreme Court dealt a big blow to President Trump immigration policies ruling Thursday that the Trump administration cannot carry out its plan to end the Deferred Action for Childhood Arrivals program, DACA, which has allowed nearly 800,000 young people, known as “Dreamers,” to avoid deportation and remain in the U.S.The decision is a big legal defeat for President Donald Trump on the issue of immigration, which has been a major focus of his domestic agenda.The ruling said the government failed to give an adequate justification for ending the federal program. The administration could try again to shut it down by offering a more detailed explanation for its action, but the White House might not want to end such a popular program in the heat of a presidential campaign.
WOMEN IN GREEN—South Carolina financier Darla Moore and former Secretary of State Condoleezza Rice will become the first women in green jackets when the Augusta National Golf Club opens for a new season in October. (AP Photos/File) by Doug FergusonAP Golf Writer NEW YORK (AP)—For the first time in its 80-year history, Augusta National Golf Club has female members.The home of the Masters, under increasing criticism the last decade because of its all-male membership, invited former Secretary of State Condoleezza Rice and South Carolina financier Darla Moore to become the first women in green jackets when the club opens for a new season in October. Both women accepted.“This is a joyous occasion,” Augusta National chairman Billy Payne said Monday.The move likely ends a debate that intensified in 2002 when Martha Burk of the National Council of Women’s Organizations urged the club to include women among its members. Former club chairman Hootie Johnson stood his ground, even at the cost of losing Masters television sponsors for two years, when he famously said Augusta National might one day have a woman in a green jacket, “but not at the point of a bayonet.”The comment took on a life of its own, becoming either a slogan of the club’s resolve not to give in to public pressure or a sign of its sexism, depending on which side of the debate was interpreting it.Payne, who took over as chairman in 2006 when Johnson retired, said consideration for new members is deliberate and private, and that Rice and Moore were not treated differently from other new members. Even so, he took the rare step of announcing two of the latest members to join because of the historical significance.“These accomplished women share our passion for the game of golf and both are well known and respected by our membership,” Payne said in a statement. “It will be a proud moment when we present Condoleezza and Darla their green jackets when the club opens this fall. This is a significant and positive time in our club’s history and, on behalf of our membership, I wanted to take this opportunity to welcome them and all of our new members into the Augusta National family.”Tiger Woods, who knows Rice through a mutual connection to Stanford, applauded the move.“I think the decision by the Augusta National membership is important to golf,” Woods said. “The Club continues to demonstrate its commitment to impacting the game in positive ways. I would like to congratulate both new members, especially my friend Condi Rice.”Augusta National, which opened in December 1932 and did not have a Black member until 1990, is believed to have about 300 members. While the club until now had no female members, women were allowed to play the golf course as guests.Rice, 57, was the national security adviser under former President George W. Bush and became secretary of state in his second term. The first Black woman to be a Stanford provost in 1993, she now is a professor of political economy at Stanford’s Graduate School of Business.“I have visited Augusta National on several occasions and look forward to playing golf, renewing friendships and forming new ones through this very special opportunity,” Rice said in a statement released by the club. “I have long admired the important role Augusta National has played in the traditions and history of golf. I also have an immense respect for the Masters Tournament and its commitment to grow the game of golf, particularly with youth, here in the United States and throughout the world.”Rice recently was appointed to the U.S. Golf Association’s nominating committee.Moore, 58, first rose to prominence in the 1980s with Chemical Bank, where she became the highest-paid woman in the banking industry. She is vice president of Rainwater, Inc., a private investment company founded by her husband, Richard Rainwater. She was the first woman to be profiled on the cover of Fortune Magazine, and she made a $25 million contribution to her alma mater, South Carolina, which renamed its business school after her.Johnson regarded the membership debate as infringing on the rights of a private club, even though every April it hosts the Masters, the most popular of the four major championships, which brings in millions of dollars through television rights for the highest-rated telecast in golf.
It was a tough afternoon for most of the girl golfers at Beau Pre but 2018’s top golfer, Molly Citro, found a way to win as she lead all golfers with an 82 to win her third round of the season, Tuesday afternoon in McKinleyville.As a team McKinleyville won its fourth round of the season, shooting a collective score of 427, 23 strokes better than second place Arcata (450). McKinleyville has won every team round this season expect for one at Baywood on Sept 13., which Citro did not compete in.Ci …
As any pro football player knows, having the proper equipment is critical to ensuring safety.New Raider Antonio Brown may not have that lesson down, leading to a painful foot condition.“Pro Football Talk Live” co-host Chris Simms reports that Brown’s blistered feet are the result of improper use of a cryotherapy machine. A team source confirmed that information to NFL Network’s Ian Rapoport on Wednesday before another practice Brown missed.Apparently Brown, the dazzling wide receiver in his …
(Visited 518 times, 2 visits today)FacebookTwitterPinterestSave分享0 Ross Anderson (PhD, biochemistry) is professor of biochemistry at The Master’s University in southern California. Dr Anderson’s expertise is in the area of biochemistry and molecular biology. He has taught Biochemistry and helped to direct research projects of graduate and medical students at Baylor College of Medicine, Houston, TX. Dr. Anderson was a post-doctoral researcher Houston Neurosensory Center, and was a member of both the undergraduate and graduate faculty at Lamar University, Beaumont, TX. Dr Anderson’s research interests include structure-function studies of DNA polymerizing enzymes and the synthesis and expression of synthetic human genes in bacterial hosts. He has authored or co-authored several publications in major, peer-reviewed journals. He is a member of the American Chemical Society and Sigma Xi Research Society. Another Attempt to Leap Over an Origin-of-Life Hurdle Falls Flatby Ross Anderson, Ph.D.Well, here they go again, trying desperately to provide a glimmer of hope to those who insist that life arose by lifeless processes. Three evolutionists are proposing that you can get polypeptides to form in water without intelligent design. Their new proposal has been published in Nature.An essential part of the evolutionary hypothesis is that life allegedly arose in the ocean, in what is sometimes referred to as the “prebiotic soup.” The major problem is that, until now, no one could explain how polymers of amino acids or other biomolecules could form in the presence of water. In the cell, amino acids are polymerized by molecular machines that can deal with the loss of a molecule of water for each peptide bond formed. Outside a cell, though, if the concentration of water is high, such as in the ocean, the reverse reaction would be favored; i.e., breaking peptide bonds is greatly favored over peptide bond formation. As a consequence, several investigators have proposed other scenarios where the water problem would be avoided, but all of these scenarios are not without their own problems.Louis Pasteur, 1822-1895, proved the “law of biogenesis” – life begets life.Ideology Driving the ExperimentationIt must be borne in mind that all hypotheses as to the abiogenetic origins of life are based on the philosophical ideology that there is no Creator, or that, if there is one, he is not involved and thus had no hand in the process. Consequently, evolutionists depend on their creative imaginations to speculate as to how life may have originated from non-life. Mind you, this is in spite of experiments done long ago by Louis Pasteur and others who demonstrated that life only originates from life. Such speculations also have to propose that the laws of thermodynamics didn’t apply at the beginning.As with virtually all attempts to show that life could have arisen abiogenetically—no intelligence involved—there is a considerable amount of intelligence used to develop the scenario proposed here. What makes this proposal unique is that it examines a means whereby polymerization of amino acids can occur in the presence of water.Here are the details. The series of reactions proposed by these authors consists of three reactions, what they refer to as the “ligation cycle.” It starts with a thiolysis reaction followed by a hydrolysis reaction. The authors start with a short N-acetylated peptide with a nitrile function on the C-terminus. Hydrogen sulfide (H2S) is used to displace the nitrile group from the N-acetyled peptide and, in the presence of water, generate an aminoacylthioacid. This thioacid is then set for the third reaction, an oxidation reaction, whereby the thioacid function is replaced by a nitrile derivative of an amino acid (aminonitrile); the next amino acid is ligated onto the C-terminus of the acetylated peptide. The peptide is thus extended by one amino acid and possess a nitrile function and activated for the next round of reactions.And yet these reactions will not spontaneously occur without copious amounts of investigator interference (i.e., intelligent design by lab workers pushing results in non-natural directions). Some examples of significant investigator input are as follows:First, all polymerization reactions in the cell require that the monomers being polymerized first be activated. In the case of protein synthesis, each amino acid is activated by attachment to a tRNA [transfer RNA]. The authors postulate some molecules could have been available in the prebiotic soup, such as ferricyanide, H2S, thioacetate, and cyanoacetylene. From that assumption, the authors concluded that formation of aminonitriles (amino acids with a nitrile function in place of the α-carboxyl group, AA-CN) would be likely. However, it was known that these do not lend themselves to efficient ligation or polymerization. They figured that if they could convert the AA-CN to an aminothioacid (AA-SH) which is stable and soluble in water, polymerization/ligation efficiency might be improved. The thiolysis and the hydrolysis reactions were shown to efficiently convert an AA-CN to an AA-SH. This, in turn, could participate in efficient ligation/polymerization of the next AA-CN to the C-terminus, and at the same time activate the -CN moiety for the next series of reactions in the cycle. [Note: moiety refers to an indefinite portion or share.]Second, the authors found that they first had to modify the peptide with an acetyl group on the N-terminus for several reasons: (1) Without the acetyl group, they were not able to observe the generation of the aminoacylthioacid by the hydrolysis reaction, and thus no ligation would be observed. (2) Without an N-acetyl group on the N-terminus of the growing peptide, it would be progressively destroyed by the activating agent diketopiperazine (DKP). (3) Addition of the acetyl group to the α-amino group of the peptide helped to activate the nitrile moiety making it amenable to thiolysis by H2S.Third, the authors start with short, pre-formed acetylated-peptides of glycine (Ac-Gly1-6-CN) to which they investigated the ligation of single aminonitriles, or pre-formed tripeptides. The amino acids used were all purified L-amino acids which doesn’t reflect the prebiotic soup conditions where a racemic mixture of both D- and L-amino acids would have existed. Unfortunately, the authors didn’t appear to investigate whether there is a limit to the iterative ligations after which yield drops significantly. This is important because the average number of amino acids in proteins today is 400-450 amino acids, with many being much longer. To get around this, some speculate that the first proteins were smaller; again, this is pure speculation. If that were the case, then what would be the advantage of making larger, more complex proteins?Fourth, the authors used ferricyanide to add the nitrile moiety to the amino acids, however, both ferricyanide and H2S are highly reactive toward each other, thus they had to be added in separate, sequential steps to achieve the results reported. Of course, in the prebiotic soup these two reagents would have been mixed together, thus compromising the results reported here.Getting the Sequence RightAs one can see, there was significant investigator involvement. Even if there wasn’t, this would not prove evolution. In all proteins there is information contained within the specific amino acid sequence, and this information is contained in the nucleic acid, DNA. It’s not enough to propose a scheme that may provide some plausible means for the abiotic synthesis of peptides. The scheme must have a way of specifying the sequence. It is the specific amino acid sequence that determines the 3-D conformation and thus function of a protein. One has to be mindful that the specific amino acid sequence in these experiments is determined by the investigators— not nature.The authors believe their work can inform theories about the origin of life:Amide bond formation is one of the most important reactions in both chemistry and biology, but there is currently no chemical method of achieving α-peptide ligation in water that tolerates all of the 20 proteinogenic amino acids at the peptide ligation site. The universal genetic code establishes that the biological role of peptides predates life’s last universal common ancestor and that peptides played an essential part in the origins of life.They conclude with sheer speculation that blind nature learned how to control metabolic reactions:Controlled synthesis, which responds to environmental or internal stimuli, is an essential element of metabolic regulation, and we speculate that coupling iterative aminonitrile ligation to metabolic (redox) cycles may lead to positive cooperative feedback during the early evolution of life.As we have shown, however, the investigators used design to push reactions against natural tendencies. Nature is the opposite of “controlled synthesis.”Rescuing Something Useful for DesignersWhile this paper really does nothing to further evolution, it does have some significance for researchers who need to make short, synthetic peptides for use in their research. To date, the “enemy” is water; all synthesis reactions have to be carried out under anhydrous [dry] conditions. Additionally, the amino acids used must have various blocking groups added to functional groups to prevent their reaction. For example, lysine has two amino groups, but only one of them (the α-amino group) is involved in peptide bond formation in proteins. The other amino group (the ε-amino group) must be prevented from participating in bond formation. Thus, it must be blocked by another moiety that can be readily removed later.Proteins are specified sequences of amino acids that fold into molecular machines and catalysts. (Illustra Media, Origin).The scheme reported here can permit synthesis of peptides in the presence of water, and no added blocking groups are needed. Additionally, the reaction scheme reported here also preserves the chirality, or handedness, of the ligated amino acids. Finally, these reactions may be carried out at various temperature and pH values with good yields. Thus, this report may significantly change the way small peptides are synthesized in the lab.It would also be interesting to investigate whether the polymerization of nucleotides into nucleic acids, like DNA and RNA, can occur under the conditions reported here. As long as materialistic ideology is not pushing the conclusions beyond what the facts warrant, and as long as results are not made to imply that nature can synthesize the “building blocks of life” blindly, or claim that this is how life started without a Creator, then the paper has some useful ideas for scientists using intelligence to build molecules by design.ReferenceCanavelli et al., “Peptide ligation by chemoselective aminonitrile coupling in water,” Nature 10 July 2019. https://www.nature.com/articles/s41586-019-1371-4
31 May 2010There will be aircraft in the skies around the clock to monitor traffic movements during the 2010 Fifa World Cup, with co-ordination provided by a national command centre and information available via a 24-hour call centre and route-planning website www.findyourway.co.za.With the kick-off to Africa’s first Fifa World Cup fast approaching, South Africa’s road and rail systems are ready to move the hundreds of thousands of fans that will be travelling countrywide.The government has invested more than R40-billion to ensure that the country’s public transport infrastructure can handle the expected one-million African visitors and over 300 000 overseas fans, while leaving behind a rich transport legacy for South Africans.The interactive website www.findyourway.co.za, featuring real-time route and traffic information, has been designed to help visitors plan their trips within and between the country’s nine World Cup host cities.Real-time information will feed into the command centre to enable quick decision-making, responses to incidents and appropriate law enforcement on routes with high traffic volumes.Major routes between host cities, airports, hotels, stadiums, fan parks, public viewing areas and other places of interest will receive priority attention.Road, rail and bus routes have been massively upgraded to provide an integrated transport system. In the major centres, this includes a bus rapid transit system featuring special public transport lanes and interchange nodes for commuters to switch from one form of transport to another.The Passenger Rail Agency of South Africa has also upgraded its infrastructure, increasing mobility and accessibility for commuters during the tournament.For intercity bus operations, a fleet of commuter buses provided by established operators in the business, as well as “midi-buses” provided by taxi operators, will provide an efficient service, with fleet usage dependent on demand.The upgrades have steered South Africa towards the biggest transport infrastructure investment in its history, becoming at the same time a project of building national unity, generating hope and repositioning the country.“It is not just about sport,” Transport Minister Sbu Ndebele said recently. “It is now truly about Tran-sport.”Source: BuaNews
NEXT BLOCK ASIA 2.0 introduces GURUS AWARDS to recognize and reward industry influencers Judge Rosemarie Aquilina said Nassar’s “decision to assault was precise, calculated, manipulative, devious, despicable.”“It is my honor and privilege to sentence you. You do not deserve to walk outside a prison ever again. You have done nothing to control those urges and anywhere you walk, destruction will occur to those most vulnerable.”FEATURED STORIESSPORTSWATCH: Drones light up sky in final leg of SEA Games torch runSPORTSLillard, Anthony lead Blazers over ThunderSPORTSMalditas save PH from shutoutNassar found competitive gymnastics to be a “perfect place” for his crimes because victims saw him as a “god” in the sport, a prosecutor said Wednesday, shortly before the former doctor was to be sentenced for years of molesting Olympic gymnasts and other young women.“It takes some kind of sick perversion to not only assault a child but to do so with her parent in the room,” prosecutor Angela Povilaitis said. “To do so while a lineup of eager young gymnasts waited.” Slow and steady hope for near-extinct Bangladesh tortoises Larry Nassar is brought into court Tuesday, Jan. 23, 2018, in Lansing, Mich. Nassar, 54, has admitted sexually assaulting athletes under the guise of medical treatment when he was employed by Michigan State University and USA Gymnastics, which as the sport’s national governing organization trains Olympians. He already has been sentenced to 60 years in prison for child pornography. Under a plea bargain, he faces a minimum of 25 to 40 years behind bars in the molestation case. (Matthew Dae Smith/Lansing State Journal via AP)LANSING, Mich. — The former sports doctor who admitted molesting some of the nation’s top gymnasts for years was sentenced Wednesday to 40 to 175 years in prison as the judge declared: “I just signed your death warrant.”The sentence capped a remarkable seven-day hearing in which scores of Larry Nassar’s victims were able to confront him face to face in a Michigan courtroom.ADVERTISEMENT MOST READ Sports venues to be ready in time for SEA Games PLAY LIST 00:59Sports venues to be ready in time for SEA Games01:27Filipino athletes get grand send-off ahead of SEA Games00:50Trending Articles01:29Police teams find crossbows, bows in HK university01:35Panelo suggests discounted SEA Games tickets for students02:49Robredo: True leaders perform well despite having ‘uninspiring’ boss02:42PH underwater hockey team aims to make waves in SEA Games01:44Philippines marks anniversary of massacre with calls for justice01:19Fire erupts in Barangay Tatalon in Quezon City Cliff Hodge return a shot in the arm for Meralco Read Next John Lloyd Cruz a dashing guest at Vhong Navarro’s wedding 2 ‘newbie’ drug pushers fall in Lucena sting Globe Business launches leading cloud-enabled and hardware-agnostic conferencing platform in PH LATEST STORIES View comments Typhoon Kammuri accelerates, gains strength en route to PH She described the “breadth and ripple” of Nassar’s sexual abuse as “nearly infinite.”“What does it say about our society that victims of sexual abuse have to hide their pain for years when they did nothing wrong? What does it say about our society when victims do come forward … and are treated as liars until proven true?” Povilaitis said.Nassar turned to the courtroom gallery to make a brief statement, saying that the accounts of more than 150 victims had “shaken me to my core.” He said “no words” can describe how sorry he is for his crimes.“I will carry your words with me for the rest of my days” he said as many of his accusers wept.ADVERTISEMENT Kammuri turning to super typhoon less likely but possible — Pagasa Brace for potentially devastating typhoon approaching PH – NDRRMC Don’t miss out on the latest news and information.