Sleep, heart disease link leads from brain to marrow

first_img The Daily Gazette Sign up for daily emails to get the latest Harvard news. Insufficient amounts in early childhood tied to cognitive, behavioral problems What’s another hour of lost sleep? For some, a hazard Both too much and too little shut-eye can be associated with health problems Study flags later risks for sleep-deprived kids Research sheds light on body clock and links to mental health and disease As daylight saving time looms, researcher sheds light on health effects of not getting enough rest center_img Related Early birds may be happier than night owls Study identifies gene regions associated with sleep duration The research, published in February in the journal Nature, was conducted with colleagues from Brigham and Women’s Hospital, Beth Israel Deaconess Medical Center, the Medical University of Vienna, and the University of Lausanne, Switzerland. It was funded by several sources, including the National Institutes of Health and the American Heart Association.Because these results were found in laboratory mice, Swirski said the next step is to search for a similar response in people. Ultimately, he and McAlpine said, the findings highlight the importance of good sleep hygiene, while the enhanced understanding of inflammatory mechanisms could provide new avenues of investigation for other conditions in which inflammation plays a role.“If these pathways are relevant in humans, and there is reason to suspect they are, then they may be very important for possible targeting of inflammation, perhaps beyond cardiovascular disease,” Swirski said. “These pathways may be relevant in cancer, infectious disease, and many other conditions where inflammatory cells play a major role.” Researchers have known for some time that poor sleep raises heart disease risk. Now, they’ve found a chemical chain reaction that helps explain that risk, leading from poor sleep to a white blood cell surge that promotes the artery-clogging plaques of cardiovascular disease.The world’s top killer, cardiovascular disease kills 17.7 million worldwide annually, according to figures from the World Health Organization. It has been linked to a number of risk factors, including smoking, a poor diet, and lack of exercise. A less widely known risk is chronically poor sleep, whether short or fragmented, like that experienced by night-shift workers, travelers in the grip of jet lag, and sufferers of sleep apnea and similar conditions.“There are studies that suggest [sleep] can be as potent a driver of the disease as more traditional risk factors, such as smoking or high cholesterol levels,” said Cameron McAlpine, a research fellow in the lab of Filip Swirski, an associate professor of radiology at Harvard Medical School and a researcher at Massachusetts General Hospital’s Center for Systems Biology.Four years ago, McAlpine, Swirski, and their colleagues began experiments designed to explore the connection between sleep and the immune and inflammatory mechanisms that play a role in atherosclerosis.Atherosclerosis, also known as hardening of the arteries, is a key feature of heart disease and has come to be understood as largely an inflammatory condition, McAlpine said. It typically advances with age as fatty plaques deposit along the walls of blood vessels, narrowing them and interfering with blood flow. The atherosclerotic plaques are made up of fats like LDL, or “bad,” cholesterol and white blood cells that flood to the scene and become entangled in fibers that hold the plaque together. The plaques not only reduce blood flow, they also can rupture and cause blood clots that clog arteries leading to the brain, causing strokes, or the heart, causing heart attacks.“The research showing a link between sleep and cardiovascular disease in humans is abundant,” Swirski said. “We wanted to know the ‘how.’ In this study we uncovered one small piece of what is surely a much larger puzzle.”Through multiple experiments, researchers found that poor sleep causes production of a protein called hypocretin to fall in the brain’s hypothalamus region, which is responsible for wakefulness, energy levels, and sleep patterns. Low hypocretin levels stimulate the bone marrow to increase production of a second protein, called colony-stimulating factor 1 (CSF-1). CSF-1, in turn, signals the bone marrow’s blood stem cells to step up production of white blood cells, boosting the immune and inflammatory response that is a feature of the condition.In their experiments, conducted on mice fed a high-fat diet and genetically preprogrammed to develop atherosclerosis, the sleep-deprived mice had more white blood cells in their bloodstreams and developed larger plaques, and those plaques contained more white blood cells than those of control mice whose sleep wasn’t disrupted. Researchers then gave supplemental hypocretin to the sleep-deprived mice and found that the prevalence of atherosclerosis declined.“The role of hypocretin was certainly very, very shocking and unexpected to us. We really didn’t know what to make of it initially,” McAlpine said. “We had no idea we would find increasing white blood cells and this production could actually be regulated by sleep.”last_img read more

Digital Darwinism: Survival of the Most Data Savvy

first_imgSomewhere, a teenage kid in his pajamas is writing code that will do what your company does for half the cost. Don’t believe me? Ask Blockbuster about Netflix. Ask Kodak about Facebook. Or ask any independent bookseller about In each of these cases, iconic brands with impressive histories were humbled by digital upstarts seemingly armed with only their Silicon Valley swagger and their venture capital fueled dreams.Actually, they were armed with something else. These darlings of the early internet harnessed the power of the internet in new ways, but their true ingenuity (and one that should serve as a model to us all today) was their understanding of three things:Intuitive Application DesignBig Data ManagementAdvanced AnalyticsMy call to action today is to learn these capabilities too or face the inevitable Digital Darwinism that awaits laggards.Train the app to the userThere was a time when people attended weeks of training to understand how to use an application. Think of the CRM or ERP applications of the past decade. Now think about that app you downloaded from the Apple or Google store this morning. Think about how you can transfer balances and deposit checks with your phone. No training required because the app was intuitive, useful, and targeted.My colleague Mike Armentano likes to remind me that the Italians have an expression to describe the best form of cooking: semplicità. Simplicity. This should be the hallmark of Third Platform applications, built quickly in the mobile age, simple in their design, and targeted rather than exhaustive in features. In this application development world, ease of use trumps feature richness. Think the iPod over the Blackberry. Think Dropbox over your corporate file share. Semplicità.In the time before Big Data was coolThink for one moment about Netflix, about the physical storage required for one movie and about the ability to stream that data in real-time. Then think about the 64MB thumb drive that you carry around with you. These technologies were impossible. Until they weren’t.The common thread for the most innovative companies is their embracing of massive data stores as the price of data storage plummeted with the onset of Big Data technologies. For example, according to the National Human Genome Institute, the cost of sequencing a gene has shrunk from roughly $100M in 2001 to roughly $7,000 in 2015. This represents a price reduction of approximately 10,000x. With this kind of cost reduction, companies can create innovative data products delivered through new channels.That’s right. I said data products. Don’t think that you need to be in the data business? Think again.What does Netflix deliver? Data…in the form of a movie. What does Facebook deliver? Data…in the form of pictures and comments. Twitter? Your bank app? That game of Candy Crush? Data, data, data.And here is the real pickle for traditional companies: upstart competitors that sell data products are getting between traditional companies and their customers. First there were organizations like Angie’s List, Kayak, and Orbitz, which could be incented to funnel customers to your door. But this has given way to data products that steal those customers from you. Consider Über’s impact on the taxi establishment or Esurance’s impact on the insurance market. These are examples of how data products attract customers to traditional products. The recipe for continued growth hinges upon the right data product to bring customers to your doorstep. Marriott’s new electronic concierge is a smart move to fend off Airbnb.Who says elephants can’t dance?Lou Gerstner, former CEO of IBM, famously asked this question in his 2004 book, challenging the widely held notion that big companies could not be innovative. Established companies have an interesting advantage – decades of information assets waiting to be combined with new internet of things data, social media data, and other exotic data. Companies have some of the best assets in the world to fuel their innovation – a long history of sales, manufacturing, service, and financial information.In today’s competitive landscape, it is imperative to leverage predictive analytics to create competitive differentiation. Target can famously (or notoriously) predict a woman’s due date within two weeks. Amazon knows what you want to buy next. Your company needs to think strategically about where analytic insights will drive the biggest ROI return. Companies have use cases as varied as prediction of ATM theft, elementary school curriculum development, eLearning planning, and utilities grid analytics for loss. The right answer for your company is one that makes you different from everyone else. We have arrived at the age of innovation, where the only answer is one that is strategically aligned to your corporate goals and helps you recognize and react to market demand faster than your competition.Call to actionIn summary, the opportunities have never been as great as they are right now to drive innovation, bringing exciting products and capabilities to customers. The key will be thinking creatively about your data assets, analytics, and application development. Each requires careful inspection to make sure that you have the capabilities to drive strategic, meaningful change. Focus on these areas will drive growth in new and exciting ways and help you recognize signals from customers, vendors, and employees, as well as machinery, equipment, transportation routes, and distribution grids.And for those struggling to make the connection between technological capabilities and business strategy, allow me to make a shameless plug for EMC’s Big Data Vision Workshop. This process has helped dozens of companies align business and IT stakeholders to identify their killer use case, driving massive value in a way that is aligned with strategy, values, and capabilities.The world is talking.  Are you listening?last_img read more

Beef war

first_imgBy Brad HaireUniversity of GeorgiaIf you like to eat beef, you may have noticed it’s costing more this summer. Consumers in other countries like fine U.S. beef, too. And they’re using their money to fight for it.With the smell of outdoor cooking filling the air, summertime is “The Grilling Season.” The U.S. beef industry sees Memorial Day through Labor Day as the high-water mark for their demand each year, says Curt Lacy, a livestock economist with the University of Georgia College of Agricultural and Environmental Sciences.Summer demandIt’s not unusual for the high demand of summer to raise retail prices for shoppers. But this year, prices are noticeably higher than normal, Lacy said.The average retail price for grade A beef cuts, like steaks and roasts, is $3.61 per pound, about 30 cents higher than this time last year, he said. (Beef prices are about 80 cents higher than they were in the summer of 1994.)The main reason for higher prices is simple: Consumers in other countries like to cook out, too. And U.S. beef is popular around the world.“U.S. consumers are having to compete against consumers in other countries for that U.S. beef,” Lacy said.Canada’s beef is also popular around the world. It normally exports as much as 60 percent of its cattle supply each year.But not this year.Beef scareIn May, Canada’s beef industry was slammed when mad cow disease, a devastating cattle disease, was discovered in a single cow in Alberta. Since then, Canadian beef has been banned or hit with high tariffs in other countries.But world consumers still want their beef. And the U.S. industry has stepped in to help supply that demand. Domestic prices have risen because of it.The good news for U.S. shoppers is that beef prices have probably peaked for now, Lacy said. Prices will begin to moderate in the second half of summer.The United States’ main global customers are Japan and Mexico. The U.S. industry supplies Japan 811 million pounds, or 45 percent of its annual beef consumption, and the bulk of Mexico’s consumption, 394 million pounds, each year.Lacy predicts U.S. cattlemen will export even more to these countries this year because Canada was also a supplier of their beef.Low weightDomestic U.S. beef prices would be higher this year even without the Canadian beef problem, Lacy said, because U.S. production is down.U.S. cattlemen are selling more cattle, but the weight of the individual animals is lower. The average weight of a steer sold this time last year was 1,252 pounds. It’s 1,221 this year.“When producers get these higher prices, they’ll try and move the cattle as quick as they can,” he said, even the lower-weight cattle.Right now, U.S. cattle producers are getting about 75 cents per pound for finished animals. That’s about 12 cents more than at this time last year.Even with higher prices, Lacy said, Georgia cattlemen should still keep a sharp eye on how and when they sell and look at new marketing opportunities.last_img read more

Last Mile Ride raises $48,000 for end-of-life care

first_imgGifford Healthcare,Gifford Medical Center’s sixth annual Last Mile Ride held on Saturday, Aug. 20, attracted a record 219 motorcyclists, 23 cyclists and raised $48,000 for end-of-life care.The charity motorcycle ride was the Randolph hospital’s sixth annual. Since it’s start in 2006, rider numbers and money raised have climbed significantly. That first year just 74 riders turned out and $7,000 was raised.The leap in participation is due to word of mouth and support for the cause, according to hospital organizers. Gifford offers special care in a garden-side suite for patients at the end-of-life. The ride supports extra services for these patients and their families and also helps patients in advanced illness or choosing to die at home with special needs and last wishes.The steady climb in dollars raised for the cause is due to the support of sponsors, including many area businesses, and riders’ fund raising efforts. Riders who raise the most win prizes.This year rider Larry Richburg of Randolph took the top prize of a $300 gift card to Wilkins Harley-Davidson in South Barre after he collected more than $2,000 for the cause.‘I’m in the Rotary Club. I hit up everybody at Rotary. I think just about everybody in Rotary donated something. I also put a little something in the church bulletin at Bethany Church. I got a lot from people at the church. I sent an e-mail to my wife’s contact list for family and friends,’ says Richburg of how he was able to raise so much.There were also people who sought out Richburg. ‘I can’t believe the number of people who just call and say ‘I have a check for you.’ It kind of goes to show what kind of fund-raiser and project this is. You don’t find that very often.’Coming in second was Frank Drown of Northfield, who raised more than $1,700, and won a leather motorcycle jacket from Frank’s Motorcycle Sales and Service in Essex Junction.Drown’s daughter Naomi spent her final days in the Garden Room at Gifford before dying at home in 2008 at the age of 25. She had a rare cancer.Since, the tight-knit Drown family has made the Last Mile Ride an annual event. This year Frank rode with daughter Alicia, daughter Olivia drove a second bike and wife Sandra rode with a friend.For Sandra, the ride is a time of reflection and healing. ‘I just love it,’ she says.For Frank, who strives to be the first one registered for the ride each year and is relentless in his fund raising efforts, the ride, in part, is a chance to help other families as his was helped.‘The benefits received by the patients and families by this fund are not replaceable by words,’ he says, using his own experience as an example. ‘We have our memories. We have our conversations. But watching the CD of the photos set to music (the family received following their stay in the Garden Room), there’s nothing that can replace that. We have that forever. Not only that, but the people involved in the Garden Room, it’s a genuine care that this fund-raiser puts forth to the families and to the patients. It’s just overwhelming.‘My personal experiences with what this program gave me drive me. I could do this every year and never replace what I got out of it.’Ride founder Lynda McDermott of Randolph, a Gifford inpatient nurse, was also once again a top fund-raiser.‘I just feel a personal responsibility,’ McDermott says. ‘When a family goes through the death of a loved one, that creates a long-term memory. These memories never go away. It’s a memory that I want to be as positive as possible. Even though it’s a sad moment, there can be a joy in this. I’m trying to help these families cherish these last times with their loved ones.’Not all participants have had an experience with the Garden Room, of course. Participants this year came from as far away as Colorado, Connecticut and Maine. For the ride, the motorcyclists traveled 112 miles around central Vermont, assisted by a group of combat veterans, who served as road guards, and Orange County Sheriff Bill Bohnyak, who led the ride.Cyclists were also a part of this year’s ride. Last year, Gifford nurse Marci White did a 38.4 mile loop from Gifford to Northfield and back. This year, other cyclists were invited to join her on the same route and Green Mountain Bike Patrol helped cyclists along the route.The ride also included a Harley raffle again this year and the winner of the 2011 Iron 883 was Rochester’s Jay McGill-O’Rourke. A long-time motorcycle enthusiast, McGill-O’Rourke was clearly thrilled to win the new Harley.‘It’s the first thing I’ve won since I was in Cub Scouts, so that was 48 years ago,’ he said.McGill-O’Rourke has been riding since he was 15 and is into collectibles. The bike he rode in Saturday’s ride was a 1974 BMW. His newest bike is 1983 Honda. ‘This will put me back in the main stream,’ he says of the new Harley he’ll soon collect from Wilkins.A quilt made by Gifford staff went to Janet Whitacker of Stockbridge, who couldn’t ride this year but stopped Saturday to make a donation and buy raffle tickets.Organizers marveled at the outpouring of support from participants and non-participants alike.‘It always amazes me the amount of support we receive for our event. To know that so many people contribute their time, resources and energy to help others who they will probably never even meet is a humbling experience,’ said Ashley Lincoln, director of development, marketing and public relations at Gifford.Photo by Robin Palmer: Motorcyclists leave Gifford Medical Center in Randolph on Saturday for the start of the Last Mile Ride.Gifford Medical Center in Randolph, Vt., is a community hospital with family health centers in Bethel, Chelsea, Rochester and Sharon and specialty services throughout central Vermont. Gifford is a full-service hospital with a 24-hour emergency department, inpatient and rehabilitation units, a day care, an adult day care and a 30-bed nursing home, the Menig Extended Care Facility, which opened in 1998 on the main campus. The Birthing Center, established in 1977, was the first in Vermont to offer an alternative to the traditional hospital-based deliveries and continues to be a leader in midwifery and family-centered care.The hospital’s mission is to improve individuals’ and community health by providing and assuring access to affordable and high-quality health care in Gifford’s service area.Next year’s ride will be held on Aug. 18.last_img read more

Why didn’t EMV prevent the Arby’s breach?

first_img“If a credit union has previously issued chip cards, how can a card still be compromised?” Very recently another major breach of payment card data was made public, this time by Arby’s. The breach compromised more than 355,000 credit and debit cards at Arby’s 1100 corporate-owned stores nationwide.  The breach, which is estimated to have occurred between Oct. 25, 2016 and January 19, 2017, involved malware placed on payment systems inside Arby’s stores. And this comes at a time when many credit unions are still recovering from the losses and costs associated with the recent Wendy’s breach, which was also large-scale, as well as massive breaches at Target and Home Depot and several others over the last two years.Many credit unions have been raising legitimate questions regarding the benefit of EMV in light of these breaches, namely:“Why doesn’t EMV (chip cards) prevent this kind of fraud?” 96SHARESShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblrcenter_img “If a credit union has not issued chip cards yet, is this a reason to?”EMV was intended to prevent counterfeit cards from being used at a POS. U.S. credit unions and banks saw about $4.5 billion in counterfeit card fraud before chip cards started being issued, which accounted for about 72% of all card fraud world-wide, since we were the last developed nation to adopt chip cards. Since then, merchants that have upgraded to chip enabled terminals have seen a 43%-54% decrease in counterfeit fraud. That number should be greater except for the many mag stripe only cards still in use. continue reading »last_img read more

NCUA announces new office to promote accountability, ethical conduct

first_imgNCUA headquarters continue reading » ShareShareSharePrintMailGooglePinterestDiggRedditStumbleuponDeliciousBufferTumblrcenter_img The NCUA Wednesday announced the creation of a new Office of Ethics Counsel, which was approved by the board during its closed meeting in March.Following allegations of misconduct at a NCUA office, NAFCU President and CEO Dan Berger earlier this year called for the agency to have better oversight and accountability.Approved by the board during its closed meeting in March, the new office will:will certify the agency’s compliance with relevant federal ethics laws and regulations;promote accountability and ethical conduct; andlast_img

Tioga, Chenango, Delaware counties coronavirus April 24 update

first_img(WBNG) — The following information is updated coronavirus from Tioga, Chenango and Delaware counties from April 24. The information released varies per county. 82 confirmed casesThree deaths58 recoveries86 are in mandatory quarantine17 people are in precautionary quarantine 67 confirmed cases43 people are in mandatory quarantineOne person is precautionary quarantine Chenango County:center_img 89 confirmed cases5 deaths21 recoveries86 people are in mandatory quarantineOne person in precautionary quarantine Tioga County: Delaware County:last_img

Tioga County to hold public hearing on changes to recycling program

first_imgLegislative Chair Martha Sauerbrey says the county’s current Recycling contract expires in January. When the county sought bids for a new one, the cost proved too expensive while providing less services. The county will hold a public hearing to introduce two new laws, one being the new recycling program while the other renews the county’s Hotel-Motel tax. She says she expects the price that residents pay to be around the same as their current recycling tax, if not slightly higher. She emphasized that it’s unlikely the cost to residents will be double the current cost, which she says would have been the case if a new contract was awarded. OWEGO (WBNG) — Changes are coming to Tioga County’s recycling program and residents will have the opportunity to give their input at a public hearing this Wednesday. “A typical room rate is $150 for a stay locally,” he says. “It’s a six dollar additional charge. That’s not going to alter your plans for that stay in any way shape or form in our opinion.” Despite the struggles that have come along with the pandemic, Lovelass says he supports keeping the tax in place. 12 News spoke with another hotel owner who didn’t want to be interviewed on camera. She said while she isn’t thrilled to have to pay the tax, she’s just happy to hear it isn’t going up. Sauerbrey says she wants to make it clear to residents that recycling in the county won’t be going away, they’re just changing the way that it’s handled. He says he does want to get the word out that by helping to cover those municipal expenses, he feels the tax is meant to help tourism, not hurt it. “The four percent is tacked onto a room charge whether you’re a hotel, a motel wherever you fall and it’s really helping to offset other municipal costs that are incurred by these guests,” he says. center_img “The recycling fee will be removed from (residents’) tax bill, so it will no longer be on their property tax bill,” she says. “They will be recycling and doing business with their garbage hauler, so it will continue but it will just be a different agreement.” The county is also introducing another law, which is a renewal of the county’s existing four-percent tax on rooms in all hotels, motels, as well as Bed & Breakfasts. Sauerbrey says the cost of recycling will be determined by the hauler, not the county, and that will replace the current recycling tax. The meeting will take place this Wednesday at the Tioga County Office Building on Main Street starting at 6 p.m. Due to COVID-19 restrictions, attendance will be limited to the first fifty residents. If you are unable to make the meeting the county will stream it on ZOOM. Ike Lovelass co-owns the Belva Lockwood Inn with his wife Julie. He says while the pandemic caused them to shut down for part of the summer, business has been robust since their reopening. He says they’ve been attracting more local visitors who are coming to explore Owego and the Finger Lakes. As a result, the county is introducing a new law stating that garbage hauling companies operating in Tioga County be required to take residents’ recycling with their garbage for an additional fee. Residents will also have the option of bringing their recyclables to a transfer station themselves. For more information on Wednesday’s meeting click here. To read the proposed law regarding recycling in Tioga County, click here.last_img read more

Buyers swoop in on Wynnum West property before auction

first_img39 Sibley Road, Wynnum WestThe expansive post-war home at 39 Sibley Rd at Wynnum West was snapped up by an interstate buyer before it went to auction.The four-bedroom house was sold for $750,000 before its scheduled March 10 auction.Selling agent Tandi Gill, from Re Max Advantage Manly, said sales in the suburb traditionally went to people from Brisbane and southeast Queensland, but this was changing.More from newsParks and wildlife the new lust-haves post coronavirus20 hours agoNoosa’s best beachfront penthouse is about to hit the market20 hours agoOutdoor living at its best.“We are getting a lot of those interstate buyers for different reasons,” she said. “Traditionally, if people were moving from interstate, they would only be looking at anywhere from 8km of the CBD.”Now interstate buyers have expanded their list of potential suburbs, with Manly West sticking out for many. Room with a view.“Obviously it is because we are not far from the water,” Ms Gill said.“I think if you were to compare our suburb with a comparative suburb in Sydney, you can see there is potential for growth.”The home has been extensively renovated over the years, with an expansive deck, a separate lockup garage and polished timber floors throughout.last_img read more

More than 30 Dead after Ferry Sinks off Indonesia

first_imgMore than 30 people died following the capsizing of a ferry in the waters off Indonesian South Sulawesi province on Tuesday.At the time of the incident, there were 189 passengers on board the KM Lestari Maju ship. 34 people died while 155 survived the incident, Sutopo Purwo Nugroho, Head of Public Relations of Indonesia’s National Disaster Mitigation Agency (BNPB), confirmed in a tweet.KM Lestari Maju alami kecelakaan laut hampir tenggelam di Perairan Selayar Kabupaten Bulukumba Provinsi Sulsel pada 3/7/2018, 14.30 WITA. Kapal membawa penumpang dan kendaraan. Diduga terjadi kebocoran lambung kiri kapal. Evakuasi dipimpin Basarnas dibantu BPBD dan aparat lain.— Sutopo Purwo Nugroho (@Sutopo_PN) July 3, 2018Search and rescue operations were launched in the afternoon hours of July 3, led by BNPB and other agencies. Despite high waves and rain, all of the victims have been evacuated, local media cited Selayar police chief as saying.The sinking has been reportedly caused by a leak in the ship’s hull.KM Lestari Maju also carried vehicles and IDR 30 billion ( around USD 2 million) in cash intended for civil servants of Selayar Islands. As informed, the money is still on the vessel, guarded by security officers, and is expected to be recovered.Yang mengapung di perairan ini bukan uang tetapi mie instan. Uang Rp 30 milyar masih berada dalam mobil Bank Sulselbar di dalam KMP Lestari Maju. Uang masih dijaga security dan akan diselamatkan.— Sutopo Purwo Nugroho (@Sutopo_PN) July 4, 2018This is the second ferry incident in the country in the past few weeks. Another ship sank in Indonesian Lake Toba, one of the world’s deepest volcanic lakes, on June 18, with nearly 200 people presumed to have drowned.World Maritime News Stafflast_img read more